基于网络药理学探究补阳还五汤治疗颈椎病的作用机制          下载免费PDF全文

王淑江  叶豪  龙胜利 《应用海洋学学报》2024,40(1):174

目的：基于网络药理学与分子对接技术分析补阳还五汤治疗颈椎病的作用机制。方法：使用TCMSP、化学专业数据库获取补阳还五汤的活性成分,并对潜在靶点进行预测及规范。分别从PharmGKB、DisGeNET、OMIM、GeneCards数据库中得到颈椎病疾病靶点,利用韦恩图获取补阳还五汤与颈椎病的交集靶点。通过CytoScape软件构建中药-活性成分-疾病靶点和蛋白质-蛋白质相互作用（PPI）网络,获得核心有效成分与关键靶点,利用David数据库对潜在靶点进行富集分析。最后运用AutoDock Vina软件对补阳还五汤核心有效成分与关键靶点进行分子对接验证。结果：共获得补阳还五汤治疗颈椎病的有效活性成分97个,包括槲皮素、山柰酚、黄芩素、木犀草素等;交集靶点64个,关键靶点有白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）、丝氨酸/苏氨酸蛋白激酶1（AKT1）、白细胞介素-1B（IL-1B）等;主要涉及肿瘤坏死因子（TNF）、白细胞介素-17（IL-17）、磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（Akt）等信号通路,分子对接结果显示核心有效成分与关键靶点之间结合紧密,为补阳还五汤治疗颈椎病提供相应条件。结论：该研究在总体上预测了补阳还五汤治疗颈椎病的活性成分、靶点和信号通路,作用途径广泛,为下一步的临床应用提供参考及思路。  相似文献   

长江口海水比重的直接测定   总被引：1，自引：0，他引：1  

闵学颐  陈国华  李飞永  于春秀 《海洋学报》1980,2(4):86-92

海水的比重是海水的一个重要物理性质,也是研究海水运动所必需的一个参数。关于大洋海水比重及其与氯度、盐度和电导的关系已有许多报导[3,5-9],为了制定新的国际海洋学常用表,Cox等人对世界各海洋表层海水的比重、盐度和温度的关系又进行了重新研究[3]。他们指出,除去低盐海水以外,所得结果与Knudsen水文表数据吻合较好,但Knudsen水文表的比重数据平均偏低0.006σ_t。  相似文献   

X₆₀钢在CO₂饱和盐水中缓蚀作用的研究     

顾锦城  李文钦  林嘉信  冯湘珠  施维新 《海洋科学》1989,13(6):16-22

本文采用动电位极化、线性极化、电偶电流和高压釜挂片失重等法,研究了含氮、硫有机缓蚀剂和/或Me~(2+)对X60钢在CO_2饱和的盐水溶液中的缓蚀作用。结果表明,含氮、硫的有机缓蚀剂在缓蚀过程中,开始是以抑制阳极过程为主,随后是以抑制阴极过程为主的混合型缓蚀剂。如与Me~(2+)复配使用,能明显地提高缓蚀效能。  相似文献   

A NUMERICAL MODEL FOR THE TIDES AND TIDAL CURRENTS IN THE TAIWAN STRAIT     

方国洪  杨景飞  赵绪才 《海洋学报(英文版)》1985,4(2):189-200

Semidiurnal and diurnal tidal waves in the Taiwan Strait are computed simultaneously by using finite difference method with two-dimensional nonlinear hydrodynamic equations. The agreement between the computed and observed results is considered satisfactory.  相似文献   

DIATOMS FROM THE SURFACE SEDIMENTS OFF THE SOUTHERN HUANGHAI SEA AND EAST CHINA SEA     

刘师成  金德祥  蓝东兆 《海洋学报(英文版)》1985,4(2):313-319

Two new species (Nitzschia sinensis Liu, sp. nov. and Podosira granulata Liu, sp. nov.) and one new variety (Xanthiopyxis microspinosa var. ellipticus Liu, var. nov.) collected from the urface sediments off the southern Huanghai Sea and the East China Sea are described and a list of diatoms from the surface sediments in the survey area and some new records in China are attached.  相似文献   

A STUDY OF MICROTEKTITES IN THE PACIFIC OCEAN     

彭汉昌  于众  缪昕  庄世杰 《海洋学报(英文版)》1984,3(1):106-113

In 1979, we found many small colorless transparent and light yellow-green glassy spherules in the surface layer and core sediment samples taken from the west of the Central Pacific Occan, which are considered to be microtektites. This finding is worthy of further determination of the range of strewn field and origin of tektites.  相似文献   

A Numerical Model of Coastal Processes of Sand Beaches Based on Long-Term Wave Series     

Zhang Changkuan  Wang Zhen  Zhang Dongsheng Associate Professor  Dept. of Navigation  Ocean Engineering  Hohai University  Nanjing Lecturer  Dept. of Navigation  Ocean Engineering  Hohai University  Nanjing Professor  Dept. of Navigation  Ocean Engineering  Hohai University  Nanjing 《中国海洋工程》1995,(2)

A numerical model of shoreline change of sand beaches based on long-term field wave data is proposed, the explicit and implicit finite difference forms of the model are described, and an application of the model is presented. Results of the application indicate that the model is sensitive to the order of the input wave data, and that the effects of long-term wave series and the effects of the mean annual wave conditions on the model are different. Instead of a single wave condition, the wave series will make the calibration and the verification of the model more practical and the results of the model more reasonable.  相似文献   

呼伦湖的近期扩张及其与全球气候变化的关系   总被引：10，自引：0，他引：10  

秦伯强  王苏民 《海洋与湖沼》1994,25(3):280-287

通过近２０多年湖泊水量平衡分析发现，湖泊水位变化主要由湖盆内径流补给量的丰枯决定。进一步分析揭示，呼伦湖地区乃至整个东北地区，本世纪以来随气温升高，随水有增加的趋势。降水增加导致入湖径流量，湖水位上升，呼伦湖本世纪以来的扩张与内蒙古东部地区其他内陆湖泊的变化一致，但这在我国乃至整个亚洲内陆干旱或半干旱区是独一无二的，为此成为这一地区气候变化的指示器。  相似文献   

应用北太平洋表层水温及环流场进行海冰预报     

臧恒范  张宝珍 《海洋学报》1980,2(4):37-47

渤海及黄海北部处在中纬度地带,每年冬季都有不同程度的结冰现象。以辽东湾结冰时间最长,全部结冰日数平均为100多天,约占全年的三分之一。从全海区看,建国后冰情较重的有1957、1968、1969、1977年的1、2月份,尤其是1969年,渤海海面发生了该海区历史上罕见的冰封,整个海面几乎全部被海冰所覆盖,严重阻碍了海上的航运交通及海上石油开采工作,从而给国民经济带来很大损失。  相似文献   

Distribution characteristics of zooplankton biomass in the East China Sea     

XU Zhaoli  CHAO Min  CHEN Yaqu 《海洋学报(英文版)》2004,23(2):337-346

On the basis of the data of oceanographic survey in the East China Sea in four seasons during 1997-2000 (23°30'~33°00'N, 118°30'-128°E), the variation of total biomass and diet biomass of zooplankton and their spatial-temporal distribution and relationship with the fishing ground of Engraulis japonicus are approached and analyzed. The results show that the average biomass is 65.32 mg/m3 in four seasons, autumn (86.18 mg/m3) being greater than summer (69.18 mg/m3) greater than spring (55.67 mg/m3) greater than winter (50.33 mg/m3). The average value of diet zooplankton biomass is 40.9 mg/m3. The trends of horizontal distribution both in the total biomass and the diet biomass of zooplankton are similar. The high biomass region (250-500 mg/m3) is very limited, only accounting for 1% of the investigation area. Seasonal variation of the biomass is very remarkable in the west and north parts of East China Sea coastal waters ( 29°30'N,125°E). The horizontal distribution of diet zooplankton depends on the  相似文献